Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets-Reference-Cited by-同舟云学术

Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets

Published:2018-02-15 Issue:7 Volume:131 Page:787-796
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Quach M. Edward¹^ORCID,Dragovich Matthew A.²,Chen Wenchun¹,Syed Anum K.¹,Cao Wenpeng²,Liang Xin¹,Deng Wei¹,De Meyer Simon F.³,Zhu Guangheng⁴,Peng Jun⁵,Ni Heyu⁴,Bennett Carolyn M.¹,Hou Ming⁵,Ware Jerry⁶,Deckmyn Hans³,Zhang X. Frank²,Li Renhao¹^ORCID

Affiliation:

1. Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA;

2. Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, PA;

3. Laboratory for Thrombosis Research, Katholieke Universiteit Leuven Campus Kulak Kortrijk, Kortrijk, Belgium;

4. Toronto Platelet Immunobiology Group and Department of Laboratory Medicine, Keenan Research Center for Biomedical Science, St. Michael’s Hospital, Toronto, ON, Canada;

5. Department of Hematology, Qilu Hospital, Shandong University, Jinan, China; and

6. Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR

Abstract

Key Points Anti-GPIbα antibodies exert a pulling force on platelet GPIbα by crosslinking platelets under shear flow. A mechanical feature of an anti-GPIbα antibody, rather than affinity or epitope, determines ability to induce Fc-independent clearance.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/7/787/1406634/blood784975.pdf

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