ATRA and ATO team up against NPM1
Author:
Affiliation:
1. VIRGINIA COMMONWEALTH UNIVERSITY
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/125/22/3369/1385779/3369.pdf
Reference11 articles.
1. Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.;Martelli;Blood,2015
2. Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1 resulting in apoptosis of AML cells.;El;Blood,2015
3. Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia.;Dos Santos;J Exp Med,2013
4. The arsenic-based cure of acute promyelocytic leukemia promotes cytoplasmic sequestration of PML and PML/RARA through inhibition of PML body recycling.;Lång;Blood,2012
5. Deguelin, a selective silencer of the NPM1 mutant, potentiates apoptosis and induces differentiation in AML cells carrying the NPM1 mutation.;Yi;Ann Hematol,2015
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