Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells-Reference-Cited by-同舟云学术

Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells

Published:2015-05-28 Issue:22 Volume:125 Page:3455-3465
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Martelli Maria Paola¹,Gionfriddo Ilaria¹,Mezzasoma Federica¹,Milano Francesca¹,Pierangeli Sara¹,Mulas Floriana¹,Pacini Roberta¹,Tabarrini Alessia¹,Pettirossi Valentina¹,Rossi Roberta¹,Vetro Calogero²,Brunetti Lorenzo¹,Sportoletti Paolo¹,Tiacci Enrico¹,Di Raimondo Francesco²,Falini Brunangelo¹

Affiliation:

1. Institute of Hematology, Centro di Ricerca Emato-Oncologico (CREO), University of Perugia, Perugia, Italy; and

2. Institute of Hematology, University of Catania, Catania, Italy

Abstract

Key Points ATRA and ATO affect NPM1 protein levels in AML cells and induce cell growth inhibition and apoptosis. AML cells with mutated NPM1 respond to ATRA/ATO, and this might be exploited therapeutically.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/22/3455/1386066/3455.pdf

Reference40 articles.

1. Impact of genetic features on treatment decisions in AML.;Dohner;Hematology Am Soc Hematol Educ Program,2011

2. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia.;Lo-Coco;N Engl J Med,2013

3. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.;Falini;N Engl J Med,2005

4. Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features.;Falini;Blood,2007

5. Role of nucleophosmin in embryonic development and tumorigenesis.;Grisendi;Nature,2005

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