Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells-Reference-Cited by-同舟云学术

Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells

Published:2015-10-08 Issue:15 Volume:126 Page:1785-1789
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ugarte Giorgia D.¹²,Vargas Macarena F.¹²,Medina Matías A.¹,León Pablo¹²,Necuñir David¹,Elorza Alvaro A.¹³,Gutiérrez Soraya E.⁴,Moon Randall T.⁵,Loyola Alejandra⁶,De Ferrari Giancarlo V.¹²

Affiliation:

1. Center for Biomedical Research, Faculty of Biological Sciences and Faculty of Medicine, Universidad Andres Bello, Santiago, Chile;

2. Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias (FONDAP) Center for Genome Regulation, Santiago, Chile;

3. Millennium Institute on Immunology and Immunotherapy, Santiago, Chile;

4. Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile;

5. Howard Hughes Medical Institute, Department of Pharmacology and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, WA; and

6. Fundación Ciencia and Vida, Santiago, Chile

Abstract

Key Points Wnt/β-catenin signaling increases ETO and Runx1 transcription in human hematopoietic progenitors. Wnt/β-catenin signaling enhances spatial proximity of ETO and RUNX1 genes and induces the generation of a recurrent translocation event.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/15/1785/1390019/1785.pdf

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4. Genetic variegation of clonal architecture and propagating cells in leukaemia.;Anderson;Nature,2011

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