Selective inhibition of cell death in malignant vs normal B-cell precursors: implications for cAMP in development and treatment of BCP-ALL-Reference-Cited by-同舟云学术

Selective inhibition of cell death in malignant vs normal B-cell precursors: implications for cAMP in development and treatment of BCP-ALL

Published:2013-03-07 Issue:10 Volume:121 Page:1805-1813
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Naderi Elin Hallan¹,Ugland Hege Katrin¹,Diep Phoi-Phoi²,Josefsen Dag³,Ruud Ellen²,Naderi Soheil¹,Blomhoff Heidi Kiil¹

Affiliation:

1. Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; and

2. Department of Paediatrics, Rikshospitalet, and

3. Department of Oncology, Radiumhospitalet, Oslo University Hospital, Oslo, Norway

Abstract

Key PointscAMP inhibits p53 accumulation and cell death in BCP-ALL cells but not normal BCPs, providing a possible therapeutic window for intervention. Activation of the PGE2-cAMP-PKA axis might be exploited by leukemic cells to suppress oncogene- and treatment-induced p53 activation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/10/1805/1362939/1805.pdf

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