Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model-Reference-Cited by-同舟云学术

Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model

Published:2019-10-28 Issue:21 Volume:3 Page:3181-3190
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Richartz Nina¹^ORCID,Duthil Eva¹,Ford Anthony²^ORCID,Naderi Elin Hallan¹³,Bhagwat Sampada¹,Gilljam Karin M.¹,Burman Marta Maria⁴,Ruud Ellen⁴⁵,Blomhoff Heidi Kiil¹,Skah Seham¹

Affiliation:

1. Department of Molecular Medicine, Institute of Basic Medicine, University of Oslo, Oslo, Norway;

2. Centre for Evolution & Cancer, The Institute of Cancer Research, London, United Kingdom;

3. Section of Head and Neck Oncology, Department of Oncology, Oslo University Hospital, Oslo, Norway;

4. Department of Hematology and Oncology, Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; and

5. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

Abstract

Key Points The COX inhibitor indomethacin delays progression of ALL in a human xenograft mouse model. The xenograft-derived ALL cells treated with indomethacin express elevated levels of p53.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/21/3181/1505839/advancesadv2019000473.pdf

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