Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model

Author:

Richartz Nina1ORCID,Duthil Eva1,Ford Anthony2ORCID,Naderi Elin Hallan13,Bhagwat Sampada1,Gilljam Karin M.1,Burman Marta Maria4,Ruud Ellen45,Blomhoff Heidi Kiil1,Skah Seham1

Affiliation:

1. Department of Molecular Medicine, Institute of Basic Medicine, University of Oslo, Oslo, Norway;

2. Centre for Evolution & Cancer, The Institute of Cancer Research, London, United Kingdom;

3. Section of Head and Neck Oncology, Department of Oncology, Oslo University Hospital, Oslo, Norway;

4. Department of Hematology and Oncology, Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; and

5. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

Abstract

Key Points The COX inhibitor indomethacin delays progression of ALL in a human xenograft mouse model. The xenograft-derived ALL cells treated with indomethacin express elevated levels of p53.

Publisher

American Society of Hematology

Subject

Hematology

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