Robust T-cell stimulation by Epstein-Barr virus–transformed B cells after antigen targeting to DEC-205-Reference-Cited by-同舟云学术

Robust T-cell stimulation by Epstein-Barr virus–transformed B cells after antigen targeting to DEC-205

Published:2013-02-28 Issue:9 Volume:121 Page:1584-1594
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Leung Carol S.¹,Maurer Michael A.²,Meixlsperger Sonja¹,Lippmann Anne¹,Cheong Cheolho³,Zuo Jianmin⁴,Haigh Tracey A.⁴,Taylor Graham S.⁴,Münz Christian¹

Affiliation:

1. Departments of Viral Immunobiology and

2. Neuroinflammation, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland;

3. Laboratory of Cellular Physiology and Immunology, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC; and

4. School of Cancer Sciences, University of Birmingham, Edgbaston, United Kingdom

Abstract

Key Points B cells contribute to MHC presentation of DEC-205–targeted antigen. Activated B cells present DEC-205–targeted antigen efficiently, because they retain it longer.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/9/1584/1368572/zh800913001584.pdf

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4. Dendritic cells: are they clinically relevant?;Palucka;Cancer J,2010

5. In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T-cell vaccination.;Bonifaz;J Exp Med,2004

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