TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL-Reference-Cited by-同舟云学术

TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL

Published:2017-08-24 Issue:8 Volume:130 Page:982-994
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kremer Kimberly N.¹,Dinkel Brittney A.¹,Sterner Rosalie M.¹²,Osborne Douglas G.¹,Jevremovic Dragan³,Hedin Karen E.¹

Affiliation:

1. Department of Immunology,

2. Mayo Clinic Medical Scientist Training Program, and

3. Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN

Abstract

Key Points T-cell activation induces TCR transactivation of CXCR4 to stabilize cytokine mRNA transcripts via a PREX1-Rac1–signaling pathway. Inhibition of the TCR-CXCR4–signaling pathway impairs TCR-dependent and TCR-independent cytokine secretion by CTCL cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/8/982/1404919/blood770982.pdf

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