Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma-Reference-Cited by-同舟云学术

Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma

Published:2017-11-30 Issue:22 Volume:130 Page:2420-2430
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Carey Christopher D.¹²,Gusenleitner Daniel³,Lipschitz Mikel³,Roemer Margaretha G. M.⁴⁵,Stack Edward C.⁶,Gjini Evisa³,Hu Xihao⁷,Redd Robert⁷,Freeman Gordon J.³⁴,Neuberg Donna⁷,Hodi F. Stephen³⁴,Liu Xiaole Shirley⁷,Shipp Margaret A.³⁴,Rodig Scott J.¹³

Affiliation:

1. Department of Pathology, Brigham and Women’s Hospital, Boston, MA;

2. Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom;

3. Center for Immuno-Oncology and

4. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

5. Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands;

6. PerkinElmer, Inc., Hopkinton, MA; and

7. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA

Abstract

Key Points Regionally localized PD-L1+ macrophages form a specialized microenvironmental niche for Hodgkin Reed-Sternberg cells in cHL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/22/2420/1403652/blood770719.pdf

Reference32 articles.

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3. PD-L1 and PD-L2 genetic alterations define classical Hodgkin lymphoma and predict outcome;Roemer;J Clin Oncol,2016

4. Classical Hodgkin lymphoma with reduced β2M/MHC class I expression is associated with inferior outcome independent of 9p24.1 status;Roemer;Cancer Immunol Res,2016

5. Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells;Reichel;Blood,2015

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