Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells-Reference-Cited by-同舟云学术

Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells

Published:2015-02-12 Issue:7 Volume:125 Page:1061-1072
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Reichel Jonathan¹²^ORCID,Chadburn Amy³,Rubinstein Paul G.⁴,Giulino-Roth Lisa¹⁵,Tam Wayne¹,Liu Yifang¹,Gaiolla Rafael¹⁶,Eng Kenneth¹,Brody Joshua⁷,Inghirami Giorgio¹,Carlo-Stella Carmelo⁸⁹,Santoro Armando⁸,Rahal Daoud⁸,Totonchy Jennifer¹,Elemento Olivier¹¹⁰,Cesarman Ethel¹^ORCID,Roshal Mikhail¹

Affiliation:

1. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY;

2. Tri-Institutional Training Program in Computational Biology and Medicine, New York, NY;

3. Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL;

4. John H. Stroger Jr Hospital of Cook County, Rush University Medical Center, Ruth M. Rothstein CORE Center, Chicago, IL;

5. Department of Pediatrics, Weill Cornell Medical College, New York, NY;

6. Botucatu School of Medicine, Sao Paulo State University, Botucatu, Brazil;

7. Icahn School of Medicine at Mount Sinai, New York, NY;

8. Humanitas Cancer Center, Humanitas Clinical and Research Center, Rozzano (Milan), Italy;

9. School of Medicine, University of Milan, Milan, Italy; and

10. Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY

Abstract

Key Points We show feasibility of whole-exome sequencing on purified primary HRS cells and report recurrent genetic alterations characterizing cHL. B2M is the most frequently mutated gene in cHL, strongly associated with nodular sclerosis subtype, younger age, and better overall survival.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/7/1061/1388622/1061.pdf

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5. MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers.;Steidl;Nature,2011

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