A meta-analysis of low-molecular-weight heparin to prevent pregnancy loss in women with inherited thrombophilia

Author:

Skeith Leslie12ORCID,Carrier Marc123,Kaaja Risto4,Martinelli Ida5ORCID,Petroff David6ORCID,Schleußner Ekkehard7,Laskin Carl A.8910ORCID,Rodger Marc A.12311ORCID

Affiliation:

1. The Ottawa Blood Disease Centre, Division of Hematology and

2. Department of Medicine, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada;

3. Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada;

4. Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland;

5. A. Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda–Ospedale Maggiore Policlinico, Milan, Italy;

6. Clinical Trial Centre, University of Leipzig, Leipzig, Germany;

7. Department of Obstetrics and Gynecology, Friedrich Schiller University Hospital, Jena, Germany;

8. LifeQuest Centre for Reproductive Medicine, Toronto, ON, Canada;

9. Department of Medicine and

10. Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada; and

11. Department of Obstetrics and Gynecology, University of Ottawa and The Ottawa Hospital, Ottawa, ON, Canada

Abstract

Abstract We performed a meta-analysis of randomized controlled trials comparing low-molecular-weight heparin (LMWH) vs no LMWH in women with inherited thrombophilia and prior late (≥10 weeks) or recurrent early (<10 weeks) pregnancy loss. Eight trials and 483 patients met our inclusion criteria. There was no significant difference in livebirth rates with the use of LMWH compared with no LMWH (relative risk, 0.81; 95% confidence interval, 0.55-1.19; P = .28), suggesting no benefit of LMWH in preventing recurrent pregnancy loss in women with inherited thrombophilia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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