Effects of low molecular weight heparin on twin pregnancies with elevated D2 dimer levels

Abstract

Abstract Backgrouds: What is the effect of low-molecular-weight heparin on twin pregnancies with increased D2 dimer following assisted reproductive technology（ART）? Methods: A retrospective cohort study. The study explored data from twin pregnancies with increased D2 dimer levels following ART who underwent foetal protection treatment at the reproductive centre of the Affiliated Hospital of Guizhou Medical University from March 2017 to December 2019. The main outcomes examined were the abortion rate of twins and the twin rate in the third trimester. Results: Twin pregnancies exhibited a lower median age and higher D2-dimer levels than single pregnancies. 400 twin pregnancies had increased D2-dimer levels. The median D2 dimer level was 1.38 ug/mL. 258 of the 400 patients received heparin medication. A multivariate analysis of each patient's pregnancy outcomes was used . The twin miscarriage rate treated with heparin was reduced by 48.3% compared to untreated pregnancies, the twin rate in the third trimester increased by 69.8%. There were no differences in twin miscarriage rate or twin rate in the third trimester of twin pregnancies between whole-course medication and early medication in the subgroup. However, there was a decrease in the NICU rate and the incidence of gestational hypertension. Conclusions: Low-molecular-weight heparin could improve the clinical outcomes of twin pregnancies following ART. Patients who undergo full therapy may see superior outcomes in comparison to those who choose early intervention.