Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15-Reference-Cited by-同舟云学术

Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

Published:2014-06-12 Issue:24 Volume:123 Page:3750-3759
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Xu Yang¹²,Zhang Ming¹,Ramos Carlos A.¹³⁴,Durett April¹,Liu Enli¹,Dakhova Olga¹,Liu Hao⁵,Creighton Chad J.⁵,Gee Adrian P.¹⁶,Heslop Helen E.¹³⁴⁶⁷,Rooney Cliona M.¹²⁶⁷,Savoldo Barbara¹⁶⁷,Dotti Gianpietro¹²⁴⁷

Affiliation:

1. Center for Cell and Gene Therapy,

2. Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX;

3. Houston Methodist Hospital, Houston, TX;

4. Department of Medicine, Baylor College of Medicine, Houston, TX;

5. Dan L. Duncan Cancer Center, Division of Biostatistics, Baylor College of Medicine, Houston, TX;

6. Department of Pediatrics, Baylor College of Medicine, Houston, TX; and

7. Texas Children’s Hospital, Houston, TX

Abstract

Key Points The frequency of CD8+CD45RA+CCR7+ cells, a subset closest to T-memory stem cells, correlates with CAR–T-cell expansion in lymphoma patients. IL-7 and IL-15 increase the frequency of CD8+CD45RA+CCR7+ cells during the ex vivo expansion of CAR+ T cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/24/3750/1377641/3750.pdf

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