Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells-Reference-Cited by-同舟云学术

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

Published:2012-05-02 Issue:132 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Scholler John¹,Brady Troy L.²,Binder-Scholl Gwendolyn¹,Hwang Wei-Ting³,Plesa Gabriela¹,Hege Kristen M.⁴,Vogel Ashley N.¹,Kalos Michael¹,Riley James L.²,Deeks Steven G.⁵,Mitsuyasu Ronald T.⁶,Bernstein Wendy B.⁷,Aronson Naomi E.⁷⁸,Levine Bruce L.¹,Bushman Frederic D.²,June Carl H.¹

Affiliation:

1. Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104–6076, USA.

2. Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104–6076, USA.

3. Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104–6076, USA.

4. Celgene Corporation, 1500 Owens Street, Suite 600, San Francisco, CA 94158, USA.

5. Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

6. Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90035, USA.

7. Walter Reed National Military Medical Center, Bethesda, MD 20889, USA.

8. Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Abstract

Adoptively transferred chimeric antigen receptor T cells have stable stem cell–like persistence for at least a decade and more than 500 years of patient safety.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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