Immature CML cells implement a BMP autocrine loop to escape TKI treatment-Reference-Cited by-同舟云学术

Immature CML cells implement a BMP autocrine loop to escape TKI treatment

Published:2017-12-28 Issue:26 Volume:130 Page:2860-2871
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Grockowiak Elodie¹²³⁴,Laperrousaz Bastien¹²³⁴⁵,Jeanpierre Sandrine¹²³⁴⁶,Voeltzel Thibault¹²³⁴,Guyot Boris¹²³⁴,Gobert Stéphanie¹²³⁴,Nicolini Franck E.¹²³⁴⁶,Maguer-Satta Véronique¹²³⁴⁷

Affiliation:

1. Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) and

2. INSERM Unité 1052, Centre de Recherche en Cancérologie de Lyon (CRCL), Lyon, France;

3. Université de Lyon, Lyon, France;

4. Department of Signaling of Tumor Escape, CRCL, Lyon, France;

5. CNRS UMR 5672, Ecole Normale Supérieure de Lyon, Lyon, France;

6. Centre Léon Bérard, Lyon, France;

7. French Group of Chronic Myeloid Leukemia (CML) (Fi-LMC), Institut Bergonié, Bordeaux, France

Abstract

Key Points TKI-resistant CML patients display persistent BMP pathway alterations in leukemic immature cells and their niche. A subpopulation of TKI-resistant leukemic stem cells survives through binding of BMP4 to BMPR1b, which preserves TWIST-1-expressing cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/26/2860/1403662/blood801019.pdf

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