CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies-Reference-Cited by-同舟云学术

CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies

Published:2017-07-20 Issue:3 Volume:130 Page:285-296
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Gomes-Silva Diogo¹²³⁴^ORCID,Srinivasan Madhuwanti¹²³,Sharma Sandhya¹²³,Lee Ciaran M.⁵,Wagner Dimitrios L.¹²³,Davis Timothy H.⁵,Rouce Rayne H.¹²³,Bao Gang⁵,Brenner Malcolm K.¹²³,Mamonkin Maksim¹²³⁶^ORCID

Affiliation:

1. Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX;

2. Texas Children's Hospital, Houston, TX;

3. Houston Methodist Hospital, Houston, TX;

4. Department of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal;

5. Department of Bioengineering, Rice University, Houston, TX; and

6. Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX

Abstract

Key Points Genomic disruption of CD7 prior to CAR transduction allows generation of CD7 CAR T cells without extensive self-antigen-driven fratricide. CD7 CAR T cells have robust activity against T-cell malignancies in vitro and in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/3/285/1404621/blood761320.pdf

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