A T-cell–directed chimeric antigen receptor for the selective treatment of T-cell malignancies-Reference-Cited by-同舟云学术

A T-cell–directed chimeric antigen receptor for the selective treatment of T-cell malignancies

Published:2015-08-20 Issue:8 Volume:126 Page:983-992
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mamonkin Maksim¹^ORCID,Rouce Rayne H.¹^ORCID,Tashiro Haruko¹^ORCID,Brenner Malcolm K.¹

Affiliation:

1. Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children’s Hospital and Houston Methodist Hospital, Houston, TX

Abstract

Key Points T cells transduced with a CD5 CAR demonstrate limited and transient fratricide and expand ex vivo. CD5 CAR T cells eliminate T-ALL blasts in vitro and control disease progression in xenograft T-ALL mouse models.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/8/983/1391789/983.pdf

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