Therapy reduction in patients with Down syndrome and myeloid leukemia: the international ML-DS 2006 trial-Reference-Cited by-同舟云学术

Therapy reduction in patients with Down syndrome and myeloid leukemia: the international ML-DS 2006 trial

Published:2017-06-22 Issue:25 Volume:129 Page:3314-3321
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Uffmann Madita¹,Rasche Mareike²,Zimmermann Martin¹,von Neuhoff Christine²,Creutzig Ursula¹,Dworzak Michael³,Scheffers Lenie⁴,Hasle Henrik⁵,Zwaan C. Michel⁴⁶,Reinhardt Dirk²,Klusmann Jan-Henning¹^ORCID

Affiliation:

1. Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany;

2. Pediatric Hematology and Oncology, Pediatrics III, Essen University Hospital, Essen, Germany;

3. Department of Pediatrics, St. Anna Children's Hospital/Children's Cancer Research Institute, Medical University of Vienna, Vienna, Austria;

4. Dutch Childhood Oncology Group, The Hague, The Netherlands;

5. Department of Pediatrics, Aarhus University Hospital, Skejby, Denmark; and

6. Department of Pediatric Oncology/Hematology, Erasmus Medical Center/Sophia Children’s Hospital, Rotterdam, The Netherlands

Abstract

Key Points Reducing therapy intensity in the ML-DS 2006 trial did not impair the excellent prognosis in ML-DS compared with the historical control. Early treatment response and gain of chromosome 8 are independent prognostic factors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/25/3314/1364442/blood765057.pdf

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4. Immunophenotype of Down syndrome acute myeloid leukemia and transient myeloproliferative disease differs significantly from other diseases with morphologically identical or similar blasts;Langebrake;Klin Padiatr,2005

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