Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice-Reference-Cited by-同舟云学术

Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice

Published:2016-12-15 Issue:24 Volume:128 Page:2774-2784
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhang Qing-Shuo¹^ORCID,Tang Weiliang²,Deater Matthew¹,Phan Ngoc¹,Marcogliese Andrea N.³,Li Hui²,Al-Dhalimy Muhsen⁴,Major Angela⁵,Olson Susan⁴,Monnat Raymond J.²⁶,Grompe Markus¹^ORCID

Affiliation:

1. Oregon Stem Cell Center, Department of Pediatrics, Oregon Health & Science University, Portland, OR;

2. Department of Pathology, University of Washington, Seattle, WA;

3. Department of Pathology, Baylor College of Medicine, TX;

4. Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR;

5. Department of Pathology, Texas Children's Hospital, Houston, TX; and

6. Department of Genome Sciences, University of Washington, Seattle, WA

Abstract

Key Points The widely used diabetes drug metformin improves hematopoiesis and delays tumor formation in a preclinical murine model of FA. Metformin reduces DNA damage in human FA patient–derived cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/24/2774/1358540/blood683490.pdf

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5. Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells;Ceccaldi;Cell Stem Cell,2012

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