Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/nature11863.pdf
Reference75 articles.
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3. Ceccaldi, R. et al. Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell 11, 36–49 (2012). This study identifies activation of the p53–p21 axis as a major contributing factor to loss of haematopoietic stem cells in Fanconi anaemia.
4. Tulpule, A. et al. Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage. Blood 115, 3453–3462 (2010).
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