Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome-Reference-Cited by-同舟云学术

Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome

Published:2016-06-02 Issue:22 Volume:127 Page:2701-2710
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hyvärinen Satu¹,Meri Seppo¹²,Jokiranta T. Sakari¹

Affiliation:

1. Department of Bacteriology and Immunology, and Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland; and

2. Helsinki University Hospital Laboratory, Helsinki, Finland

Abstract

Key Points Sialic acids are critical for factor H–mediated complement regulation on endothelial cells, erythrocytes, and platelets. Impaired ability of factor H mutants to simultaneously bind sialic acid and C3b on cells explains their association with aHUS.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/22/2701/1393587/2701.pdf

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