1. Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, London, United Kingdom;
2. UCL Genetics Institute, London, United Kingdom;
3. Centre for Cardiovascular Genetics, Department of Medicine, University College London, London, United Kingdom;
4. Translational Medicine & Therapeutics, William Harvey Research Institute, Barts & The London, Queen Mary, University of London, London, United Kingdom; and
5. Respiratory CEDD, GlaxoSmithKline, Stevenage, United Kingdom