Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia
Author:
Affiliation:
1. Institute for Drug Development, Cancer Therapy and Research Center at the University of Texas Health Science Center at San Antonio;
2. Millennium Pharmaceuticals, Cambridge, MA; and
3. University College Hospital, Galway, Ireland
Abstract
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/115/18/3796/1326007/zh801810003796.pdf
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3. A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment.;Burnett;Cancer,2007
4. An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.;Ohh;EMBO Rep,2002
5. Function and regulation of cullin-RING ubiquitin ligases.;Petroski;Nat Rev Mol Cell Biol,2005
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