Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells-Reference-Cited by-同舟云学术

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

Published:2016-11-24 Issue:21 Volume:128 Page:2568-2579
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Furlan Scott N.¹²³^ORCID,Watkins Benjamin¹²³,Tkachev Victor¹²³,Cooley Sarah⁴^ORCID,Panoskaltsis-Mortari Angela⁴,Betz Kayla¹²³,Brown Melanie¹²³,Hunt Daniel J.¹²³,Schell John B.¹²³,Zeleski Katie¹²³,Yu Alison¹²³,Giver Cynthia R.⁵,Waller Edmund K.⁵,Miller Jeffrey S.⁴,Blazar Bruce R.⁴,Kean Leslie S.¹²³

Affiliation:

1. Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute, Seattle, WA;

2. Department of Pediatrics, University of Washington, Seattle, WA;

3. Fred Hutchinson Cancer Research Center, Seattle, WA;

4. Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN; and

5. Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA

Abstract

Key PointsThe transcriptional networks controlling breakthrough acute GVHD can be mapped, and correlate closely with clinical disease. Breakthrough acute GVHD is transcriptionally controlled by T-cell persistence, inflammation, and Th/Tc17 skewing.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/21/2568/1397461/blood726547.pdf

Reference59 articles.

1. Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation;McDonald-Hyman;Sci Transl Med,2015

2. Organ Procurement and Transplantation Network. Available at: http://optn.transplant.hrsa.gov/.

3. Advances in graft-versus-host disease biology and therapy;Blazar;Nat Rev Immunol,2012

4. GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression;Miller;Blood,2010

5. CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis;Kaliyaperumal;Blood,2014

Cited by 39 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The graft versus leukemia effect: donor lymphocyte infusions and cellular therapy;Frontiers in Immunology;2024-03-15

2. Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates;Science Translational Medicine;2023-06-28

3. Engineering T cells to suppress acute GVHD and leukemia relapse after allogeneic hematopoietic stem cell transplantation;Blood;2023-03-09

4. Milestones in acute GVHD pathophysiology;Frontiers in Immunology;2022-12-05

5. Evolutionarily conserved effects of Notch signaling drive intestinal graft-versus-host disease in mice and non-human primates;2022-04-27