FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII-Reference-Cited by-同舟云学术

FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII

Published:2017-01-12 Issue:2 Volume:129 Page:238-245
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Yoon Jeongheon¹,Schmidt Anja²,Zhang Ai-Hong¹,Königs Christoph²,Kim Yong Chan¹,Scott David W.¹

Affiliation:

1. Department of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD; and

2. Department of Pediatrics, Molecular Hemostasis and Immunodeficiency, University Hospital Frankfurt, Goethe University, Frankfurt, Germany

Abstract

Key Points Generation and functional analysis of FVIII-specific human CAR Tregs. Specific regulation of FVIII responses by engineered human CAR Tregs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/2/238/1400478/blood727834.pdf

Reference20 articles.

1. The hemophilias--from royal genes to gene therapy;Mannucci;N Engl J Med,2001

2. Rate of inhibitor development in previously untreated hemophilia A patients treated with plasma-derived or recombinant factor VIII concentrates: a systematic review;Iorio;J Thromb Haemost,2010

3. First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells;Trzonkowski;Clin Immunol,2009

4. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics;Brunstein;Blood,2011

5. Adoptive transfer of umbilical cord blood-derived regulatory T cells and early viral reactivation;Brunstein;Biol Blood Marrow Transplant,2013

Cited by 117 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Role of FoxP3⁺ Regulatory T Cells in Modulating Immune Responses to Adeno-Associated Virus Gene Therapy;Human Gene Therapy;2024-07-01

2. Chimeric antigen receptor T cell therapy for autoimmune disease;Nature Reviews Immunology;2024-06-03

3. The enchanting canvas of CAR technology: Unveiling its wonders in non-neoplastic diseases;Med;2024-06

4. Induction of FoxP3 Pre-mRNA Alternative Splicing to Enhance the Suppressive Activity of Regulatory T Cells from Amyotrophic Lateral Sclerosis Patients;Biomedicines;2024-05-07

5. Reprogramming T cells as an emerging treatment to slow human age-related decline in health;Frontiers in Medical Technology;2024-04-11