G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2

Author:

Kawano Yuko1,Fukui Chie1,Shinohara Masakazu23,Wakahashi Kanako1,Ishii Shinichi1,Suzuki Tomohide1,Sato Mari14,Asada Noboru1,Kawano Hiroki1,Minagawa Kentaro1,Sada Akiko1,Furuyashiki Tomoyuki5,Uematsu Satoshi67,Akira Shizuo89,Uede Toshimitsu10,Narumiya Shuh11,Matsui Toshimitsu12,Katayama Yoshio1

Affiliation:

1. Hematology, Department of Medicine,

2. The Integrated Center for Mass Spectrometry, and

3. Department of Community Medicine and Social Health Care, Division of Epidemiology, Kobe University Graduate School of Medicine, Kobe, Japan;

4. Department of Oral Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan;

5. Division of Pharmacology, Kobe University Graduate School of Medicine, Kobe, Japan;

6. Department of Mucosal Immunology, School of Medicine, Chiba University, Chiba, Japan;

7. Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan;

8. Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan;

9. Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan;

10. Department of Matrix Medicine, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan;

11. Department of Drug Discovery Medicine and Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan; and

12. Department of Hematology, Nishiwaki Municipal Hospital, Nishiwaki, Japan

Abstract

Key Points G-CSF-induced sympathetic tone provokes fever and modulates microenvironment via PGE2 production by bone marrow Gr-1high neutrophils.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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