Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells-Reference-Cited by-同舟云学术

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

Published:2013-03-14 Issue:11 Volume:121 Page:1995-2007
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ikushima Yoshiko Matsumoto¹²,Arai Fumio¹,Hosokawa Kentaro¹,Toyama Hirofumi¹,Takubo Keiyo¹,Furuyashiki Tomoyuki³,Narumiya Shuh³,Suda Toshio¹

Affiliation:

1. Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan;

2. Research Fellow of the Japan Society for the Promotion of Science; and

3. Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto, Japan

Abstract

Key Points PGE2 signaling positively regulates hematopoietic stem cells both directly and via activation of a nonhematopoietic cell population. EP4 is a major receptor for the PGE2-mediated regulation of hematopoietic stem and progenitor cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/11/1995/1363829/1995.pdf

Reference43 articles.

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4. Cyclooxygenases: structural, cellular, and molecular biology.;Smith;Annu Rev Biochem,2000

5. Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances.;Legler;Int J Biochem Cell Biol,2010

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