A novel role for C3 in antibody-induced red blood cell clearance and antigen modulation

Author:

Girard-Pierce Kathryn R.1,Stowell Sean R.1,Smith Nicole H.2,Arthur C. Maridith1,Sullivan Harold C.1,Hendrickson Jeanne E.12,Zimring James C.3

Affiliation:

1. Department of Pathology and

2. Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA; and

3. Puget Sound Blood Center, Seattle, WA

Abstract

Key Points Transfused murine RBCs expressing the KEL2 antigen induce polyclonal anti-KEL glycoprotein antibodies capable of fixing complement. Complement plays a role in incompatible RBC clearance and modulation of the KEL2 antigen on transfused RBCs.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference35 articles.

1. Complement.;Müller-Eberhard;Annu Rev Biochem,1969

2. Complement. First of two parts.;Walport;N Engl J Med,2001

3. Complement. Second of two parts.;Walport;N Engl J Med,2001

4. The role of complement in antibody-mediated red-cell destruction.;Mollison;Br J Haematol,1970

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