An animal model of adult T-cell leukemia: humanized mice with HTLV-1–specific immunity-Reference-Cited by-同舟云学术

An animal model of adult T-cell leukemia: humanized mice with HTLV-1–specific immunity

Published:2014-01-16 Issue:3 Volume:123 Page:346-355
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Tezuka Kenta¹,Xun Runze¹,Tei Mami¹,Ueno Takaharu¹,Tanaka Masakazu¹,Takenouchi Norihiro¹,Fujisawa Jun-ichi¹

Affiliation:

1. Department of Microbiology, Kansai Medical University, Hirakata, Osaka, Japan

Abstract

Key Points Humanized mice, IBMI-huNOG, were generated by intra–bone marrow injection of human CD133+ hematopoietic stem cells. HTLV-1–infected IBMI-huNOG mice recapitulated distinct ATL-like symptoms as well as HTLV-1–specific adaptive immune responses.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/3/346/1377620/346.pdf

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