Author:
Boxus Mathieu,Twizere Jean-Claude,Legros Sébastien,Dewulf Jean-François,Kettmann Richard,Willems Luc
Abstract
Abstract
The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Virology
Cited by
216 articles.
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