Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia-Reference-Cited by-同舟云学术

Effects of eltrombopag on platelet count and platelet activation in Wiskott-Aldrich syndrome/X-linked thrombocytopenia

Published:2015-09-10 Issue:11 Volume:126 Page:1367-1378
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Gerrits Anja J.¹,Leven Emily A.²,Frelinger Andrew L.¹,Brigstocke Sophie L.²,Berny-Lang Michelle A.¹,Mitchell W. Beau²³,Revel-Vilk Shoshana⁴,Tamary Hannah⁵,Carmichael Sabrina L.¹,Barnard Marc R.¹,Michelson Alan D.¹,Bussel James B.²

Affiliation:

1. Center for Platelet Research Studies, Division of Hematology/Oncology, Boston Children’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

2. Division of Pediatric Hematology/Oncology, New York Presbyterian Hospital/Weill Cornell Medical College, New York, NY;

3. Platelet Biology Laboratory, New York Blood Center, New York, NY;

4. Department of Pediatric Hematology/Oncology, Hadassah Hebrew University Hospital, Jerusalem, Israel; and

5. Pediatric Hematology Oncology, Schneider Children’s Medical Center of Israel, Petah Tikva, Israel

Abstract

Key Points Platelet function in WAS/XLT, measured by agonist-induced surface-activated GPIIb-IIIa and P-selectin, is proportional to platelet size. Eltrombopag increased platelet counts, but did not improve platelet activation, in most WAS/XLT patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/11/1367/1387606/1367.pdf

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