Dendritic cells accumulate in the bone marrow of myeloma patients where they protect tumor plasma cells from CD8+ T-cell killing

Author:

Leone Patrizia1,Berardi Simona1,Frassanito Maria Antonia1,Ria Roberto1,De Re Valli2,Cicco Sebastiano1,Battaglia Stefano1,Ditonno Paolo3,Dammacco Franco1,Vacca Angelo1,Racanelli Vito1

Affiliation:

1. Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy;

2. Bio-Proteomics Facility, Department of Translational Research, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy; and

3. Hematology Unit, Di Venere Hospital, Bari, Italy

Abstract

Key Points Dendritic cells accumulate in the bone marrow of multiple myeloma patients. Bone marrow dendritic cells play a dual, but opposing, role in multiple myeloma.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference35 articles.

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