Platelet binding sites for factor VIII in relation to fibrin and phosphatidylserine-Reference-Cited by-同舟云学术

Platelet binding sites for factor VIII in relation to fibrin and phosphatidylserine

Published:2015-09-03 Issue:10 Volume:126 Page:1237-1244
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Gilbert Gary E.¹²,Novakovic Valerie A.¹,Shi Jialan¹²,Rasmussen Jan³,Pipe Steven W.⁴

Affiliation:

1. Departments of Medicine and Research, VA Boston Healthcare System, Boston, MA;

2. Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA;

3. Protein Chemistry Laboratory, Department of Molecular Biology, University of Aarhus, Aarhus, Denmark; and

4. Departments of Pediatrics and Pathology, University of Michigan, Ann Arbor, MI

Abstract

Key Points Coagulation fVIII binds to a protein complex, including fibrin, on stimulated platelets rather than to membrane PS. Anti-fVIII antibodies inhibit function on platelets differently than on phospholipid vesicles used in clinical assays.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/10/1237/1388499/1237.pdf

Reference44 articles.

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4. Binding of human blood-coagulation Factors IXa and X to phospholipid membranes.;Mertens;Biochem J,1984

5. The effect of plasma von Willebrand factor on the binding of human factor VIII to thrombin-activated human platelets.;Nesheim;J Biol Chem,1991

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