NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity-Reference-Cited by-同舟云学术

NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity

Published:2015-09-10 Issue:11 Volume:126 Page:1324-1335
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ochodnicka-Mackovicova Katarina¹²,Bahjat Mahnoush¹²,Bloedjes Timon A.¹²,Maas Chiel¹²,de Bruin Alexander M.¹²,Bende Richard J.¹²,van Noesel Carel J. M.¹²,Guikema Jeroen E. J.¹²^ORCID

Affiliation:

1. Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; and

2. Lymphoma and Myeloma Center Amsterdam, Amsterdam, The Netherlands

Abstract

Key Points NF-κB and AKT signaling prevent RAG-dependent DNA damage in cycling-transformed pre-B cells. NF-κB activity negatively correlates with RAG expression in B-ALL patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/11/1324/1387757/1324.pdf

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4. Receptor editing: an approach by autoreactive B cells to escape tolerance.;Gay;J Exp Med,1993

5. Receptor editing in self-reactive bone marrow B cells.;Tiegs;J Exp Med,1993

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