A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance-Reference-Cited by-同舟云学术

A novel role for the macrophage galactose-type lectin receptor in mediating von Willebrand factor clearance

Published:2018-02-22 Issue:8 Volume:131 Page:911-916
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ward Soracha E.¹,O’Sullivan Jamie M.¹,Drakeford Clive¹,Aguila Sonia¹,Jondle Christopher N.²,Sharma Jyotika²,Fallon Padraic G.³,Brophy Teresa M.¹,Preston Roger J. S.¹,Smyth Paul⁴,Sheils Orla⁴,Chion Alain¹,O’Donnell James S.¹⁵

Affiliation:

1. Irish Centre for Vascular Biology, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland;

2. Department of Basic Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND;

3. Inflammation and Immunity Research Group, Trinity Translational Medicine Institute, and

4. Department of Histopathology, Trinity Translational Medicine Institute, Trinity College Dublin, St. James’s Hospital, Dublin, Ireland; and

5. National Centre for Coagulation Disorders, St. James’s Hospital, Dublin, Ireland

Abstract

Key Points VWF sialylation modulates in vivo clearance through Ashwell-Morrell independent pathways. VWF binding to MGL plays a novel role in facilitating VWF clearance.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/8/911/1466713/blood787853.pdf

Reference25 articles.

1. Clearance of von Willebrand factor;Casari;J Thromb Haemost,2013

2. von Willebrand factor arginine 1205 substitution results in accelerated macrophage-dependent clearance in vivo;Rawley;J Thromb Haemost,2015

3. Mapping the N-glycome of human von Willebrand factor;Canis;Biochem J,2012

4. The plasma von Willebrand factor O-glycome comprises a surprising variety of structures including ABH antigens and disialosyl motifs;Canis;J Thromb Haemost,2010

5. Expression of terminal alpha2-6-linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13;McGrath;Blood,2010

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