Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma

Author:

Matthews Julie Marie12,Bhatt Shruti2,Patricelli Matthew P.3,Nomanbhoy Tyzoon K.3,Jiang Xiaoyu1,Natkunam Yasodha4,Gentles Andrew J.56,Martinez Ezequiel7,Zhu Daxing1,Chapman Jennifer Rose8,Cortizas Elena9,Shyam Ragini10,Chinichian Shideh10,Advani Ranjana10,Tan Li1112,Zhang Jianming1112,Choi Hwan Geun12,Tibshirani Robert13,Buhrlage Sara J.12,Gratzinger Dita4,Verdun Ramiro9,Gray Nathanael S.1112,Lossos Izidore S.127

Affiliation:

1. Division of Hematology-Oncology, Department of Medicine, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL;

2. Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL;

3. ActivX Biosciences, Inc, La Jolla, CA;

4. Department of Pathology and

5. Center for Cancer Systems Biology, Stanford University School of Medicine, Stanford, CA;

6. Department of Radiology, Stanford University, Stanford, CA;

7. Department of Cancer Biology,

8. Department of Pathology, Sylvester Comprehensive Cancer Center, and

9. Division of Gerontology and Geriatric Medicine, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL;

10. Oncology Division, Stanford University School of Medicine, Stanford, CA;

11. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA;

12. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA; and

13. Department of Health Research and Policy, and Department of Statistics, Stanford University, Stanford, CA

Abstract

Key Points GCK signaling is activated in DLBCL, and this signaling is important to DLBCL proliferation and survival. Therapeutic targeting of GCK is feasible and may advance efforts to cure DLBCL patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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