Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides-Reference-Cited by-同舟云学术

Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides

Published:2015-07-23 Issue:4 Volume:126 Page:508-519
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

McGirt Laura Y.¹²,Jia Peilin³⁴,Baerenwald Devin A.²,Duszynski Robert J.⁵,Dahlman Kimberly B.⁶⁷,Zic John A.²,Zwerner Jeffrey P.²,Hucks Donald⁶,Dave Utpal⁸⁹,Zhao Zhongming³⁴⁷¹⁰,Eischen Christine M.⁵

Affiliation:

1. Department of Hematology/Oncology, Levine Cancer Institute, Carolinas Medical Center, Charlotte, NC; and

2. Department of Medicine/Division of Dermatology,

3. Department of Biomedical Informatics,

4. Center for Quantitative Sciences,

5. Department of Pathology, Microbiology and Immunology,

6. Vanderbilt-Ingram Cancer Center,

7. Department of Cancer Biology,

8. Department of Medicine/Division of Hematology-Oncology,

9. Tennessee Valley Healthcare System, and

10. Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN

Abstract

Key Points High-throughput sequencing of MF revealed multiple mutations within epigenetic and cytokine pathways that may drive disease. Pharmacologically targeting the JAK3 pathway in MF results in cell death and may be an effective treatment of this disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/4/508/1390920/508.pdf

Reference68 articles.

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5. miR-223 regulates cell growth and targets proto-oncogenes in mycosis fungoides/cutaneous T-cell lymphoma.;McGirt;J Invest Dermatol,2014

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