SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts-Reference-Cited by-同舟云学术

SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts

Published:2015-07-09 Issue:2 Volume:126 Page:233-241
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Malcovati Luca¹²,Karimi Mohsen³,Papaemmanuil Elli⁴,Ambaglio Ilaria²⁵,Jädersten Martin³,Jansson Monika³,Elena Chiara¹²,Gallì Anna²,Walldin Gunilla³,Della Porta Matteo G.²⁵,Raaschou-Jensen Klas⁶,Travaglino Erica²,Kallenbach Klaus⁷,Pietra Daniela²,Ljungström Viktor⁸,Conte Simona³,Boveri Emanuela⁹,Invernizzi Rosangela⁵¹⁰,Rosenquist Richard⁸,Campbell Peter J.⁴,Cazzola Mario¹²,Hellström Lindberg Eva³

Affiliation:

1. Department of Molecular Medicine, University of Pavia, Pavia, Italy;

2. Department of Hematology Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy;

3. Center for Hematology and Regenerative Medicine, Karolinska University Hospital, Stockholm, Sweden;

4. Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom;

5. Department of Internal Medicine, University of Pavia, Pavia, Italy;

6. Department of Hematology and

7. Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark;

8. Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden;

9. Department of Pathology, and

10. Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

Abstract

Key Points In MDS with ring sideroblasts, SF3B1 mutation defines a homogeneous subgroup with isolated erythroid dysplasia and favorable prognosis. MDS with ring sideroblasts and wild-type SF3B1 is mainly characterized by multilineage dysplasia and unfavorable prognosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/2/233/1390331/233.pdf

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5. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts.;Papaemmanuil;N Engl J Med,2011

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