Cladribine and cytarabine in refractory multisystem Langerhans cell histiocytosis: results of an international phase 2 study-Reference-Cited by-同舟云学术

Cladribine and cytarabine in refractory multisystem Langerhans cell histiocytosis: results of an international phase 2 study

Published:2015-09-17 Issue:12 Volume:126 Page:1415-1423
ISSN:0006-4971
Container-title:Blood
language:en
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Author:

Donadieu Jean¹^ORCID,Bernard Frederic²,van Noesel Max³,Barkaoui Mohamed¹,Bardet Odile⁴,Mura Rosella⁵,Arico Maurizio⁶,Piguet Christophe⁷,Gandemer Virginie⁸,Armari Alla Corinne⁹,Clausen Niels¹⁰,Jeziorski Eric²,Lambilliote Anne¹¹,Weitzman Sheila¹²,Henter Jan Inge¹³,Van Den Bos Cor¹⁴,

Affiliation:

1. Service d’Hémato-Oncologie Pédiatrique, Hopital Trousseau, Paris Registre des Histiocytoses Centre de Référence des Histiocytoses, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France;

2. Hémato Oncologie Pédiatrique, Centre Hospitalier Universitaire (CHU) de Montpellier, Montpellier, France;

3. Department of Pediatric Hematology Oncology, Erasmus MC–Sophia’s Children’s Hospital, Rotterdam, The Netherlands;

4. Direction Recherche et Innovation, Centre Hospitalier Régional Universitaire (CHRU) Montpellier–Centre Administratif André Benech, Montpellier, France;

5. Pediatric Hematology Oncology, Ospedale microcetemico, Cagliari, Italy;

6. Pediatric Hematology Oncology, Azienda Sanitaria Provinciale, Ragusa, Italy;

7. Pediatric Hémato Oncology, CHU, Limoges, France;

8. Pediatric Hémato Oncology, CHU, Rennes, France;

9. Pediatric Hémato Oncology, CHU, Grenoble, France;

10. Pediatric Hematology Oncology, Universitets Hospital of Aarhus at Skejby, Aarhus, Denmark;

11. Pediatric Hémato Oncology, Hopital Jean De Flandre, CHU, Lille, France;

12. Pediatric Hematology Oncology, The Hospital for Sick Children, Toronto, ON, Canada;

13. Department of Women’s and Children’s Health, Karolinska Institute, Karolinska Univeristy Hospital, Stockholm Sweden; and

14. Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands

Abstract

Key Points Patients with LCH, risk organs, refractory to standard VBL-steroid regimen have a poor survival, ∼30%. In a phase 2 study, with 5 years’ median follow-up, cladribine and Ara-C was shown to improve the survival up to 85% for this group.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/12/1415/1387731/1415.pdf

Reference29 articles.

1. A randomized trial of treatment for multisystem Langerhans’ cell histiocytosis.;Gadner;J Pediatr,2001

2. Improved outcome in multisystem Langerhans cell histiocytosis is associated with therapy intensification.;Gadner;Blood,2008

3. Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis.;Gadner;Blood,2013

4. Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years.;Haupt;Pediatr Blood Cancer,2013

5. Response to initial treatment of multisystem Langerhans cell histiocytosis: an important prognostic indicator.;Minkov;Med Pediatr Oncol,2002

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