The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation-Reference-Cited by-同舟云学术

The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation

Published:2013-10-17 Issue:16 Volume:122 Page:2812-2822
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wang Tao¹²,Nandakumar Vijayalakshmi¹,Jiang Xiao-Xia¹,Jones Lindsey¹,Yang An-Gang²,Huang Xue F.¹,Chen Si-Yi¹

Affiliation:

1. Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA; and

2. State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi’an, China

Abstract

Key Points Mysm1 is required to maintain the quiescence and pool size of HSC, and its deletion severely impairs the survival and function of HSC. Mysm1 controls HSC homeostasis by regulating Gfi1 expression via modulating histone modifications and transcriptional factors recruitment.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/16/2812/1369885/2812.pdf

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