A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice-Reference-Cited by-同舟云学术

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice

Published:2018-05-24 Issue:21 Volume:131 Page:e1-e11
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Dahlin Joakim S.¹²^ORCID,Hamey Fiona K.¹^ORCID,Pijuan-Sala Blanca¹,Shepherd Mairi³,Lau Winnie W. Y.¹,Nestorowa Sonia¹,Weinreb Caleb⁴,Wolock Samuel⁴,Hannah Rebecca¹,Diamanti Evangelia¹,Kent David G.³,Göttgens Berthold¹,Wilson Nicola K.¹

Affiliation:

1. Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research and Wellcome–Medical Research Council Cambridge Stem Cell Institute, Cambridge, United Kingdom;

2. Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden;

3. Department of Haematology, University of Cambridge, Wellcome–Medical Research Council Cambridge Stem Cell Institute, Cambridge, United Kingdom; and

4. Department of Systems Biology, Harvard Medical School, Boston, MA

Abstract

Key Points Single-cell transcriptional landscape of 44 802 hematopoietic stem/progenitor cells defines entry points to 8 different blood lineages. Comparison with 13 815 c-Kit mutant cells identifies pleiotropic changes in cell type abundance and underlying molecular profiles.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/21/e1/1468628/blood821413.pdf

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