Distinct routes of lineage development reshape the human blood hierarchy across ontogeny-Reference-Cited by-同舟云学术

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

Published:2016-01-08 Issue:6269 Volume:351 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Notta Faiyaz¹²,Zandi Sasan¹²,Takayama Naoya¹²,Dobson Stephanie¹²,Gan Olga I.¹,Wilson Gavin²³,Kaufmann Kerstin B.¹²,McLeod Jessica¹,Laurenti Elisa⁴,Dunant Cyrille F.⁵,McPherson John D.⁶³,Stein Lincoln D.²³,Dror Yigal⁷,Dick John E.¹²

Affiliation:

1. Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.

2. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

3. Ontario Institute for Cancer Research, Toronto, Ontario, Canada.

4. Wellcome Trust, Medical Research Council Cambridge Stem Cell Institute, Department of Haematology, University of Cambridge, Cambridge, UK.

5. Ecole Polytechnique Fédérale de Lausanne, LMC, Station 12, Lausanne, CH-1015, Switzerland.

6. Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

7. The Hospital for Sick Children Research Institute, University of Toronto, Ontario, Canada.

Abstract

Adjusting hematopoietic hierarchy In adults, more than 300 billion blood cells are replenished daily. This output arises from a cellular hierarchy where stem cells differentiate into a series of multilineage progenitors, culminating in unilineage progenitors that generate over 10 different mature blood cell types. Notta et al. mapped the lineage potential of nearly 3000 single cells from 33 different cell populations of stem and progenitor cells from fetal liver, cord blood, and adult bone marrow (see the Perspective by Cabezas-Wallscheid and Trumpp). Prenatally, stem cell and progenitor populations were multilineage with few unilineage progenitors. In adults, multilineage cell potential was only seen in stem cell populations. Science , this issue p. 10.1126/science.aab2116 ; see also p. 126

Funder

Canadian Institute of Health Research (CIHR)

Aplastic Anemia and Myelodysplasia Association of Canada

Ontario Institute of Cancer Research (OICR)

Ontario Ministry of Research and Innovation

Wellcome Trust

Canadian Cancer Society

Terry Fox Foundation

Ontario Genomics Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject