Cell rigidity and shape override CD47’s “self”-signaling in phagocytosis by hyperactivating myosin-II-Reference-Cited by-同舟云学术

Cell rigidity and shape override CD47’s “self”-signaling in phagocytosis by hyperactivating myosin-II

Published:2015-01-15 Issue:3 Volume:125 Page:542-552
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sosale Nisha G.¹^ORCID,Rouhiparkouhi Tahereh²,Bradshaw Andrew M.¹,Dimova Rumiana²,Lipowsky Reinhard²,Discher Dennis E.¹

Affiliation:

1. Molecular and Cell Biophysics Laboratory, University of Pennsylvania, Philadelphia, PA; and

2. Max Planck Institute of Colloids and Interfaces, Potsdam, Germany

Abstract

Key Points Rigidity of an opsonized red cell that contacts a macrophage is found to hyperactivate myosin-II and thus overpowers CD47’s self-signaling. Red cell shape modulates CD47’s signaling of self and highlights biophysical contributions to phagocytosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/3/542/1344895/542.pdf

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