Complement in antibody therapy: friend or foe?
Author:
Affiliation:
1. OSPEDALI RIUNITI DI BERGAMO
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/114/26/5247/1320086/zh805109005247.pdf
Reference8 articles.
1. Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis.;Golay;Blood,2000
2. Anti-CD20 monoclonal antibodies—historical and future perspectives [published online ahead of print September 22, 2009].;Lim;Haematologica
3. Depletion of the C3 component of complement enhances the ability of rituximab-coated target cells to activate human NK cells and improves the efficacy of monoclonal antibody therapy in an in vivo model.;Wang;Blood,2009
4. NK-cell activation and antibody-dependent cellular cytotoxicity induced by rituximab-coated target cells is inhibited by the C3b component of complement.;Wang;Blood,2008
5. Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation.;Beers;Blood,2008
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