A trial of unrelated donor marrow transplantation for children with severe sickle cell disease

Author:

Shenoy Shalini1,Eapen Mary2,Panepinto Julie A.23,Logan Brent R.2,Wu Juan4,Abraham Allistair5,Brochstein Joel6,Chaudhury Sonali7,Godder Kamar8,Haight Ann E.9,Kasow Kimberly A.10,Leung Kathryn11,Andreansky Martin12,Bhatia Monica13,Dalal Jignesh14,Haines Hilary15,Jaroscak Jennifer16,Lazarus Hillard M.17,Levine John E.18,Krishnamurti Lakshmanan19,Margolis David3,Megason Gail C.20,Yu Lolie C.21,Pulsipher Michael A.22,Gersten Iris4,DiFronzo Nancy23,Horowitz Mary M.2,Walters Mark C.24,Kamani Naynesh25

Affiliation:

1. Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO;

2. Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI;

3. Children’s Hospital of Wisconsin, Milwaukee, WI;

4. The Emmes Corporation, Rockville, MD;

5. Children’s National Medical Center, Washington, DC;

6. Steven and Alexandra Cohen Children’s Medical Center, New Hyde Park, NY;

7. Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL;

8. Department of Pediatrics, Virginia Commonwealth University, Richmond, VA;

9. Department of Pediatrics, Children’s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA;

10. Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC;

11. Department of Pediatrics, Baylor College of Medicine, Houston, TX;

12. Department of Pediatrics, University of Miami, Miami, FL;

13. Columbia University Medical Center, New York, NY;

14. Children’s Mercy Hospital and Clinics, Kansas City, KS;

15. Department of Pediatrics, University of Alabama, Birmingham, AL;

16. Department of Pediatrics, Medical University of South Carolina, Charleston, SC;

17. Department of Internal Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH;

18. Departments of Internal Medicine and Pediatrics, University of Michigan, Ann Arbor, MI;

19. Children’s Hospital of Pittsburgh, Pittsburgh, PA;

20. University of Mississippi Medical Center, Jackson, MS;

21. Louisiana State University Medical Center, Children’s Hospital of New Orleans, New Orleans, LA;

22. Pediatric Blood and Marrow Transplant Consortium, Salt Lake City, UT;

23. National Heart, Lung, and Blood Institute, Bethesda, MD;

24. UCSF Benioff Children’s Hospital, Oakland, CA; and

25. AABB Center for Cellular Therapies, Bethesda, MD

Abstract

Key Points Children with sickle cell disease engrafted unrelated donor marrow after reduced intensity conditioning. A high incidence of GVHD and associated mortality compromised safety of the trial.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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