Outcome of patients with hemoglobinopathies given either cord blood or bone marrow transplantation from an HLA-identical sibling

Author:

Locatelli Franco12,Kabbara Nabil3,Ruggeri Annalisa3,Ghavamzadeh Ardeshir4,Roberts Irene5,Li Chi Kong6,Bernaudin Françoise7,Vermylen Christiane8,Dalle Jean-Hugues9,Stein Jerry10,Wynn Robert11,Cordonnier Catherine12,Pinto Fernando5,Angelucci Emanuele13,Socié Gérard14,Gluckman Eliane3,Walters Mark C.15,Rocha Vanderson316

Affiliation:

1. Department of Pediatric Hematology-Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy;

2. University of Pavia, Pavia, Italy;

3. Eurocord, Hôpital Saint Louis, Paris, France;

4. Hematology Oncology and Bone Marrow Transplant Department, Shariati Hospital, Tehran, Iran;

5. Hematology Department, Hammersmith Hospital, London, United Kingdom;

6. Pediatric Department, Prince of Wales Hospital, Shatin, Hong Kong;

7. Reference Center for Sickle Cell Disease, Intercommunal Hospital, Créteil, France;

8. Pediatric Hematology and Oncology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium;

9. Pediatric Hematology Department, Hôpital Robert Debré, Paris, France;

10. Bone Marrow Transplantation Unit, Schneider Children’s Medical Center of Israel, Petach-Tikva, Israel;

11. Royal Manchester Children’s Hospital, Manchester, United Kingdom;

12. Hematology Department, Hôpital Henri Mondor, Créteil, France;

13. EBMT Hemoglobinopathy Registry;

14. Hematology-Bone Marrow Transplantation Department, Hôpital Saint Louis, Paris, France;

15. Blood and Marrow Transplant Program, Children’s Hospital and Research Center, Oakland, CA; and

16. Haematology Department, Bone Marrow Transplant Unit, University of Oxford, Oxford, United Kingdom

Abstract

Key Points Patients with thalassemia major or sickle cell disease had excellent outcomes after both CBT and BMT from an HLA-identical sibling. Related cord blood transplantation is a suitable transplant option for patients with hemoglobinopathies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference38 articles.

1. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine.;Borgna-Pignatti;Haematologica,2004

2. Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major.;Borgna-Pignatti;Blood,2006

3. Sickle-cell disease.;Rees;Lancet,2010

4. Marrow transplantation for thalassaemia.;Thomas;Lancet,1982

5. Bone marrow transplantation in thalassemia. The experience of Pesaro.;Lucarelli;Ann N Y Acad Sci,1998

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