Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes-Reference-Cited by-同舟云学术

Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes

Published:2016-11-24 Issue:21 Volume:128 Page:2550-2560
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Urrutia Andres A.¹^ORCID,Afzal Aqeela¹²^ORCID,Nelson Jacob¹,Davidoff Olena¹³,Gross Kenneth W.⁴,Haase Volker H.¹³⁵^ORCID

Affiliation:

1. Department of Medicine and

2. Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN;

3. Medical and Research Services, Department of Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, TN;

4. Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY; and

5. Departments of Cancer Biology and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN

Abstract

Key Points Pericytes function as oxygen sensors and are major sites of erythropoietin production in the hypoxic brain. The ability to synthesize erythropoietin is a functional feature of pericytes in the brain and kidney.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/21/2550/1397316/blood713545.pdf

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