Erythrocytosis: the HIF pathway in control-Reference-Cited by-同舟云学术

Erythrocytosis: the HIF pathway in control

Published:2013-08-15 Issue:7 Volume:122 Page:1122-1128
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Franke Kristin¹,Gassmann Max²³,Wielockx Ben¹⁴

Affiliation:

1. Emmy Noether Research Group, Institute of Pathology, University of Technology, Dresden, Germany;

2. Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology (ZIHP), Zurich, Switzerland;

3. Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru; and

4. DFG Research Center and Cluster of Excellence for Regenerative Therapies Dresden, University of Technology, Dresden, Germany

Abstract

Abstract Organisms living under aerobic conditions need oxygen for the metabolic conversion of nutrition into energy. With the appearance of increasingly complex animals, a specialized transport system (erythrocytes) arose during evolution to provide oxygen to virtually every single cell in the body. Moreover, in case of low environmental partial pressure of oxygen, the number of erythrocytes automatically increases to preserve sustained oxygen delivery. This process relies predominantly on the cytokine erythropoietin (Epo) and its transcription factor hypoxia inducible factor (HIF), whereas the von Hippel-Lindau (VHL) ubiquitin ligase as well as the oxygen-sensitive prolyl hydroxylases (PHDs) represent essential regulators of this oxygen-sensing system. Deregulation of particular members of this pathway (eg, PHD2, HIF2α, VHL) lead to disorders in blood homeostasis as a result of insufficient (anemia) or excessive (erythrocytosis) red blood cell production.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/7/1122/1373531/1122.pdf

Reference100 articles.

1. Purification of human erythropoietin.;Miyake;J Biol Chem,1977

2. Isolation and characterization of genomic and cDNA clones of human erythropoietin.;Jacobs;Nature,1985

3. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.;Semenza;Mol Cell Biol,1992

4. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.;Wang;Proc Natl Acad Sci USA,1995

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