Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis

Author:

Lee Stanley C. W.12,Miller Sarah1,Hyland Craig1,Kauppi Maria12,Lebois Marion1,Di Rago Ladina1,Metcalf Donald12,Kinkel Sarah A.12,Josefsson Emma C.12,Blewitt Marnie E.123,Majewski Ian J.12,Alexander Warren S.12

Affiliation:

1. The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia;

2. Department of Medical Biology and

3. Department of Genetics, University of Melbourne, Parkville, VIC, Australia

Abstract

Key Points Inactivation of Suz12 results in a rapid and marked exhaustion of the HSC pool. Lymphoid development is completely dependent on PRC2, but numerous myeloid lineages develop in the absence of PRC2.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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