Lyn sustains oncogenic signaling in chronic lymphocytic leukemia by strengthening SET-mediated inhibition of PP2A-Reference-Cited by-同舟云学术

Lyn sustains oncogenic signaling in chronic lymphocytic leukemia by strengthening SET-mediated inhibition of PP2A

Published:2015-06-11 Issue:24 Volume:125 Page:3747-3755
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zonta Francesca¹,Pagano Mario Angelo²,Trentin Livio³⁴,Tibaldi Elena¹,Frezzato Federica³⁴,Trimarco Valentina³⁴,Facco Monica³⁴,Zagotto Giuseppe²,Pavan Valeria²,Ribaudo Giovanni²,Bordin Luciana¹,Semenzato Gianpietro³⁴,Brunati Anna Maria¹

Affiliation:

1. Department of Molecular Medicine,

2. Department of Pharmaceutical and Pharmacological Sciences, and

3. Department of Medicine, University of Padua, Padua, Italy; and

4. Venetian Institute of Molecular Medicine, Centro di Eccellenza per la Ricerca Biomedica, Padua, Italy

Abstract

Key Points Cytosolic HSP90-bound Lyn mediates resistance to apoptosis by strengthening PP2A/SET interaction in CLL cells. FTY720-analogues antagonizing the PP2A/SET interaction and Lyn inhibitors may provide a therapeutic approach of CLL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/24/3747/1387561/3747.pdf

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